Welcome
We are interested in targets of the maternally deposited transcription factor, Dorsal, which is present in a nuclear gradient along the dorsoventral axis of embryos. Half the known Dorsal targets are transcription factors or signaling pathway components. Many of these genes are responsible for controlling the cell movements and differentiation events that occur during gastrulation. Our initial studies have focused on two new Dorsal target genes we uncovered using microarray analysis, the FGF-ligands Pyramus and Thisbe.